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Gene and Cellular Immunotherapy for Cancer [electronic resource]
Ghobadi, Armin
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| 자료유형 | 단행본 |
|---|---|
| 개인저자 | Ghobadi, Armin.,editor. DiPersio, John F.,editor. |
| 단체저자명 | SpringerLink (Online service). |
| 서명/저자사항 | Gene and Cellular Immunotherapy for Cancer [electronic resource] / edited by Armin Ghobadi, John F. DiPersio. |
| 판사항 | 1st ed. 2022. |
| 형태사항 | X, 378 p. 29 illus., 28 illus. in color:online resource. |
| 총서사항 | Cancer Drug Discovery and Development=2196-9914 |
| 총서부출표목 | Cancer Drug Discovery and Development, |
| 기본자료 저록 | Springer Nature eBook |
| 기타형태 저록 | Printed edition:9783030878481Printed edition:9783030878504Printed edition:9783030878511 |
| ISBN | 9783030878498 |
| 기타표준부호 | 10.1007/978-3-030-87849-8 |
| 내용주기 | The History of Cellular Therapies -- Basics of Immunity -- Biology of CAR T cells -- Cell types used for CAR generation -- Combination therapeutics with CART cell therapy -- Safety switches used for cellular therapies -- Off-the-shelf CAR-T -- Manufacturing of CAR-T Cells: the Assembly Line -- Navigating Regulations in Gene and Cell Immunotherapy -- Bringing CAR-T to the Clinic -- CAR T-Cell Complications -- Mechanisms of Resistance and Relapse after CAR T cell therapy -- Tumor infiltrating lymphocytes (TIL): from bench to bedside -- T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic -- Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside -- Biology of NK cells and NK cells in clinic -- Biology and Clinical Evaluation of T/NK Cell Engagers -- Roadmap for Starting an Outpatient Cellular Therapy Program -- Index. |
| 요약 | Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field. |
| 일반주제명 | Medicine—Research. Biology—Research. Medical microbiology. Pharmacology. Biomedical Research. Medical Microbiology. Pharmacology. |
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