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Translational Pancreatic Cancer Research From Understanding of Mechanisms to Novel Clinical Trials [electronic resource]
Michalski, Christoph W
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| 자료유형 | 단행본 |
|---|---|
| 개인저자 | Michalski, Christoph W.,editor. Rosendahl, Jonas.,editor. Michl, Patrick.,editor. Kleeff, Jörg.,editor. |
| 단체저자명 | SpringerLink (Online service). |
| 서명/저자사항 | Translational Pancreatic Cancer Research [electronic resource] : From Understanding of Mechanisms to Novel Clinical Trials / edited by Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff. |
| 판사항 | 1st ed. 2020. |
| 형태사항 | XII, 245 p. 18 illus., 17 illus. in color:online resource. |
| 총서사항 | Molecular and Translational Medicine=2197-7860 |
| 총서부출표목 | Molecular and Translational Medicine, |
| 기본자료 저록 | Springer Nature eBook |
| 기타형태 저록 | Printed edition:9783030494759Printed edition:9783030494773Printed edition:9783030494780 |
| ISBN | 9783030494766 |
| 기타표준부호 | 10.1007/978-3-030-49476-6 |
| 내용주기 | Subtypes of Pancreatic Adenocarcinoma -- Surveillance and Intervention in IPMN -- Novel Biomarkers of Invasive IPMN -- Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for protein biomarkers -- Metabolic Biomarkers of Pancreatic Cancer -- Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Drugable Biomarkers for Pancreatic Ductal Adenocarcinoma -- Circulating tumor DNA as a novel biomarker for pancreatic cancer -- PDAC Subtypes/Stratification -- Circulating Tumor Cells as Biomarkers in Pancreatic Cancer -- Personalized Models of Human PDAC -- Therapeutic Targeting of Stromal Components -- Epigenetic Targeting -- Targeting Metabolism -- Targeting the Immune System in Pancreatic Cancer -- Phase I Trials in Pancreatic Cancer -- Translational Approaches in Surgical Treatment. |
| 요약 | This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice. |
| 일반주제명 | Oncology. Pathology. Oncology. Pathology. |
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