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The Biology of Senescence A Translational Approach [electronic resource]
Swynghedauw, Bernard
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| 자료유형 | 단행본 |
|---|---|
| 개인저자 | Swynghedauw, Bernard.,author. |
| 단체저자명 | SpringerLink (Online service). |
| 서명/저자사항 | The Biology of Senescence [electronic resource] : A Translational Approach / by Bernard Swynghedauw. |
| 판사항 | 1st ed. 2019. |
| 형태사항 | XI, 121 p. 23 illus., 13 illus. in color:online resource. |
| 총서사항 | Practical Issues in Geriatrics=2509-6079 |
| 총서부출표목 | Practical Issues in Geriatrics, |
| 기본자료 저록 | Springer Nature eBook |
| 기타형태 저록 | Printed edition:9783030151102Printed edition:9783030151126Printed edition:9783030151133 |
| ISBN | 9783030151119 |
| 기타표준부호 | 10.1007/978-3-030-15111-9 |
| 내용주기 | 1. Introduction -- 2. The emerging medical landscape -- 3. Origins of ageing -- 4. The senescent cell -- 5. « Benign » clinical manifestations and their relationships with the senescent cell -- 6. Age-linked non transmissible diseases -- 7. The senescent cardiovascular system -- 8. « To treat» or prevent ageing -- 9. Senescence and darwinian evolution -- 10. Conclusions -- 11. Summary -- 12. Annexes -- 13. References. |
| 요약 | This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians. |
| 일반주제명 | Geriatrics. Family medicine. Medical genetics. Geriatrics. General Practice and Family Medicine. Medical Genetics. |
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